Wednesday, December 28, 2011

Combinatorial roles of nuclear receptors

Lately, Ive been thinking about how GR and CREB (activated by BDNF) could be regulating genes in a combinatorial fashion. I found this paper that talks about LXR, GR, and PPARs role in combinatorial regulation of inflammatory genes.

Thought it would be a nice review to guide our thinking about potential mechanism especially for some of the more complicated genes like CCR7.

http://www.nature.com/nri/journal/v6/n1/full/nri1748.html

Figure 4 Derepression as a prerequisite to activation of nuclear-receptor and inflammatory-response genes.


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2 comments:

  1. MaryemDecember 28, 2011 at 8:28 PM

    Hey Marcus, Im having trouble finding the link to the actual paper. can you post the link again please? thanks!

    ReplyDelete
  2. thelegacymakerDecember 30, 2011 at 5:37 PM

    Sorry, here's the link: http://www.nature.com/nri/journal/v6/n1/full/nri1748.html

    ReplyDelete

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