Combinatorial roles of nuclear receptors

Lately, Ive been thinking about how GR and CREB (activated by BDNF) could be regulating genes in a combinatorial fashion. I found this paper that talks about LXR, GR, and PPARs role in combinatorial regulation of inflammatory genes.

Thought it would be a nice review to guide our thinking about potential mechanism especially for some of the more complicated genes like CCR7.

http://www.nature.com/nri/journal/v6/n1/full/nri1748.html

Figure 4 Derepression as a prerequisite to activation of nuclear-receptor and inflammatory-response genes.

Fighting breast cancer with flaxseeds

An interesting article forwarded to me by a friend:

http://www.diseaseproof.com/archives/breast-cancer-fighting-breast-cancer-with-flaxseeds.html