Few interesting studies brought this group to investigate the role of LXR in prostate cancer; LXR is involved in lipid metabolism and cholesterol has a role in tumor development, together with LNCaP xenografts in high cholesterol diet mice that showed increase apoptosis and phospho-signaling.
This group connected the dots and investigated LXR activation in LNCaP in vitro and in vivo and showed very nicely the important role of it in contributing to the cancer apoptosis through downregulation of the AKT pathway.
